As the growth factor signaling pathways that regulate p27 in normal cells and lead to its deregulation in cancers are elucidated, it is to be hoped that therapeutic avenues for the restoration of p27 function will emerge.
Although its normal functions are yet to be clearly elucidated, it is presumed to be involved in adhesion, growth, proliferation and differentiation [31].
Although the mechanisms by which RFX1 exerts its activation or repression activity have only been partially elucidated, it is known that RFX1 behaves as a potent transcriptional repressor in CD4+ T cells [ 10].
Once the mechanisms are more clearly elucidated, it may steer researchers on a path towards much-needed treatments.
In this chapter they provide interesting examples of a number of complex natural products that can be elucidated it with this system.
Although the mechanism of hypercoagulability in patients with cancer has not been fully elucidated, it is thought that tumour cells express tissue factors that activate the coagulation cascade, including cellular procoagulants such as tumour procoagulant and factor X receptors.
As the role of mental health in outcomes studies after joint replacement becomes increasingly elucidated, it seems pertinent that mental health should be regarded as a comorbidity and accounted for in a comorbidity index.
Although the underlying mechanisms responsible for cardiac dysfunction after prolonged exercise remains to be elucidated, it has reported cardiac deterioration following exhaustive exercise in the absence of underlying cardiovascular diseases, which has been attributed to cardiac fatigue.
Although the pathogenesis has not been completely elucidated, it appears that not only the uterus, but also the follicle and oocyte, are affected by excessive plasma urea nitrogen (PUN) concentrations.
Although the precise molecular mechanisms underlying this preference need to be elucidated, it appears that bone microenvironments possess unique biological features that enable circulating cancer cells to home, survive and proliferate, and destroy bone.
With the impact of landscape amelioration or damage being elucidated, it also makes it possible to adjust benefits among concerned people, and may help public landscape management sectors optimize their budget plans.
