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While the functionality of the NF1-LRD has yet to be elucidated in the context of full neurofibromin protein, it has been hypothesized that NF1-LRD may function as a scaffold protein to interact with phospholipids for membrane localization owing to its SEC14 domain that is adjacent to the GAP domain and the PH-like domain that associate with proteins involved in signal transduction.
Adding to the merits, MTD-SE PSCs also demonstrate significantly suppressed photo-current hysteretic behaviour which has been elucidated in the context of faster ion migration kinetics with the increased grain boundaries, which exhibit higher ionic diffusivity.
These results suggest that SIRT3 possesses the tumor-type dependent function and its precise role needs to be elucidated in the context of a specific cancer.
This effect was first elucidated in the context of the arabinose operon [8].
The transcriptional mechanisms underlying this bidirectional control of β2-subunit expression, however, remain to be elucidated in the context of changes in β1 and β3 subunit expression in human and old tg CaV1.2 mouse heart failure.
There is, however, a more complicated feedback mechanism between aPKC and Zif that has yet to be completely elucidated in the context of regulation of neuroblast self-renewal.
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This can be elucidated also in the context of the electron transfer from the hydrogen-bond acceptor atom and the resulting partial neutralization of the positive charges on H.intra atoms.
Thus, the exact role of sPLA2 in AIDs, in addition to its pro-inflammatory role, remains to be elucidated, especially in the context of cardiovascular complications observed in these diseases.
The mechanisms of hypoxia and HIF stabilisation must be elucidated further in the context of in vivo disease models to identify successful avenues for drug discovery and development against disease.
Further work will be needed to understand the full spectrum of VPS35 and retromer function on cellular homeostasis, but these models provide a platform with which to elucidate this in the context of the ageing brain.
Authoritative and practical, Epistasis: Methods and Protocols aids scientists in continuing to study elucidate epistasis in the context of modern data availability.
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