Thus, elucidating downstream genes/signaling pathways and molecular mechanisms of TH actions is critical for the treatment of significant public health issues.
Further studies are needed to elucidate downstream mechanisms of AS regulation, and novel functional isoforms are potential targets in future functional researches.
The D-loop is one of the first intermediates of HR, and here we aimed to reconstitute DNA repair synthesis and strand displacement machinery in vitro, utilizing this substrate, to elucidate downstream events in HR.
Notably, N. benthamiana is widely used as system for transient over-expression and silencing of various genes involved in plant innate immunity to elucidate downstream signaling events after PAMP-mediated priming.
Further deciphering of the complexities of breast cancer signal transduction pathways, their regulation and interplay, including elucidating downstream gene effects, is important, not least because therapeutic resistance is a persistent problem for all therapies targeting known pathways.
To identify molecular processes induced in the liver of mice treated with two structurally distinct SIRT1 activators, SIRT501 (formulated resveratrol) and SRT1720, for three days, we utilized a systems biology approach and applied Causal Network Modeling (CNM) on gene expression data to elucidate downstream effects of SIRT1 activation.
While seminal studies have partially elucidated events downstream of bipotent TECs in relation to the emergence of mTECs and their progenitors, the control and timing of the emergence of the cTEC lineage, particularly in relation to that of mTEC progenitors, has remained elusive.
In this way, Indian researchers have been able to identify genes involved in development and stress response and elucidate downstream genes and pathways.
In vitro and in vivo studies with entities from distinct structural classes have helped elucidate the downstream pharmacological responses associated with IRAK4 inhibition as a proof of concept in disease models, leading to the recent initiation of human clinical trials.
Future studies are necessary to elucidate the downstream target of caspase-9.
