The anti-inflammatory mechanisms of these nanoparticles remain to be elucidated, though their beneficial roles in allergy and autoimmune diseases suggest their suppressive potential in acquired immunity.
The role of the observed induction of SREBP-2 and its target genes in TAIII cytotoxicity remains to be elucidated, though it is unlikely to be directly relevant to cell death, because SREBP-2 is induced in relatively resistant MCF10A cells.
The cause of neurodegeneration in AD has yet to be elucidated, though several pathogenic mechanisms have been postulated, including mitochondrial dysfunction and the accumulation of Aβ.
The targets and exact function of IL-33 in the nucleus remain to be elucidated, though it is thought that IL-33 may exhibit transcriptional repressor activity 20.
Cranberries' mechanism of action has not been fully elucidated, though it is thought to be attributed to two components, proanthocyanidins and fructose [ 20].
The precise sperm AR signaling pathways are not completely elucidated, though several tentative signaling pathway mechanisms of ZP-initiated AR have been proposed.
The mechanisms to explain associations of diet with inflammation and insulin resistance have not been fully elucidated, though several theories have been suggested.
The interplay between these receptors in ILC is yet to be fully elucidated, though it is clear the high frequency of hormone receptor expression reflects the overall good response to endocrine-based therapies [ 2].
The mechanism by which feed restriction regulates follicle number has not been completely elucidated, though it is known to influence Gonadotrophin Releasing Hormone (GnRH) secretion within the hypothalamo-pituitary-gonadal (HPG) axis [ 8, 9].
The actual mechanisms by which Cl-amidine reduces cellular proliferation have yet to be fully elucidated, though evidence here suggests that PADI2 may play a role (direct or indirect) in regulating the expression of both cell cycle and tumor promoting genes.
