Whereas some approaches in bioethics proceed by applying principles derived from independent ethical theories to individual cases (a "top-down" approach), others proceed by examining individual cases in order to elucidate the principles that seem to guide most people's thinking about bioethical issues in actual practice (a "bottom-up" approach).
The 3D EM structures of the hDmc1-ssDNA filaments allowed us to elucidate the principles of their internal architecture.
The 3D EM structure of the filament is consistent with previous biochemical and x-ray crystallography data, and allows us to elucidate the principles of its internal architecture.
Efforts to elucidate the principles underlying mixture pleasantness have so far met with limited success.
To elucidate the principles behind successful drug combinations, examples of known successful and unsuccessful drug combinations are needed.
Memory distortions have attracted the interest of psychologists and cognitive neuroscientists because of their potential to elucidate the principles of human memory functioning (Schacter et al. 1998).
This systematic and quantitative analysis begins to elucidate the principles governing RNA recognition by a site-specific endonuclease and may thus serve as a mechanistic model for investigating other RNA modifying enzymes.
In order to elucidate the principles of the shorter CSL of pex mutants relative to the WT control, as well as the mutual differences between the pex mutants studied, we investigated the fate of peroxisomes during chronological aging in WT cells.
Despite the possible advantages for clinical applications, more work remains to be done to elucidate the principles of biological design, and to overcome the scientific and technical challenges in designing and building more effective systems that are harmless to humans and therefore useful for clinical applications.
Richter, the French chemist Joseph-Louis Proust, and the English chemist John Dalton, despite their theoretical insights, had contributed little empirical evidence toward elucidating the principles of chemical combination.
Bacon described spectacles (which also soon came into use); elucidated the principles of reflection, refraction, and spherical aberration; and proposed mechanically propelled ships and carriages.
