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As residue conservation indicates functional importance, comparison of natural binder sequences could in principle elucidate the preference of their target binding site.
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A general sequence is proposed to elucidate the preferences of various hexagonal sites (H-sites) and triangular sites (T-sites), that is, tetrahedrally substituted H-sites > nonsubstituted H-sites > tetrahedrally substituted T-sites > nonsubstituted T-sites, but the influence of octahedral substitutions on the preference of the neighboring sites is not obvious.
Although providing accurate ethical and understandable descriptions of randomisation is important, there is surprisingly little direct research elucidating the preferences of patients (Corbett et al, 1996; Featherstone and Donovan, 2002; Jenkins et al, 2002; Simon et al, 2004).
To elucidate the cleavage preferences of MMPs, we employed a high-throughput multiplexed peptide-centric profiling technology involving the cleavage of 18,583 peptides by 18 proteinases from the main sub-groups of the MMP family.
This study was designed to elucidate the contemporary practice preferences of cardiac surgeons regarding different phases of management of acute type A aortic dissection.
DOI: http://dx.doi.org/10.7554/eLife.04630.018 Collectively our results elucidate the basis for the physiological preference of the DEAD-box protein Mss116 for ATP and RNA, but also show that the helicase core has a surprising degree of substrate ambiguity.
Expanding this molecular evolutionary research to non-traditional model organisms will help elucidate the breadth of this phenomenon and the role of evolution of amino acid preferences in promoting translational efficiency.
Elucidate the role of ERBB2 and EGFR-driven lung cancer.
Therefore, to elucidate the mechanism of this attenuation, the effects of pretreatment with κ- and δ-receptor antagonists, nor-binaltorphimine (nor-BNI) and naltrindole (NTI), on the development of the morphine-induced place preference under inflammation were examined.
To elucidate the source of this residual broadening, we investigate the birefringence of the HC-PCF.
Mice with targeted deletion of ETT may help elucidate the importance of ET for normal physiology.
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