Sentence examples for elucidate the mode of from inspiring English sources

To elucidate the mode of action of FRE, its effects on a battery of targets involved in glucose homeostasis was evaluated.

To elucidate the mode of action of BAY 2402234, MOLM-13 xenograft-bearing mice were treated with a single 5 mg/kg dose of BAY 2402234 and tumors were collected at five time points (3, 6, 24, 36, and 48 h) after treatment with BAY 2402234 or vehicle control and were subjected to RNA-sequencing.

Further studies to elucidate the mode of action revealed that these three compounds induced G0/G1 cell cycle arrest and apoptosis, which was accompanied by loss of mitochondrial membrane potential, DNA fragmentation and nuclear morphology in HL-60 cells.

Information about the receptor-interaction region of Cry toxins, insecticidal proteins produced by Bacillus thuringiensis, is needed to elucidate the mode of action of Cry toxins and improve their toxicity through protein engineering.

The present study was designed to elucidate the mode of action of isoproterenol (Isp; adrenergic β-agonist) and to characterize the effect of the calcitonin gene-related peptide (CGRP; sensory neuropeptide) on osteoclast formation induced by Isp in a mouse bone marrow culture system.

One important task is now to elucidate the mode of action of those compounds.

Understanding the specific physiology of Daphnia may help to elucidate the modes of action of environmental toxicants [ 48, 49].

In a pioneering study, [ 14] exposed a pool of 233 heterozygous mutants to sub-lethal compound concentrations, and later work has successfully elucidated the mode-of-action of novel compounds such as the anti-tumour agent dihydromotuporamine C [ 15], demonstrating the utility of such genome-wide yeast screens.

The molecular modulation was conceptualized by M.G. and J.V.M., who also performed the characterization of molecular modulators and contributed to elucidating the mode of action.

Subsequent research, reported elsewhere, has elucidated the mode of action and assessed its potential relevance to humans.

Elucidating the mode of action and thereby opening the way to the design of chemotherapeutic agents is one of the major goals of metal-based anticancer research.