Although the mechanism underlying these changes remains to be elucidated, the combination of the five-chemical mixture is suggested to result in the abnormal upregulation of the DNA-methylating system, including DNA methyltransferase enzymes.
While the precise molecular mechanism has still to be elucidated, the combination of murine and pediatric OI data should make clinicians more attentive to extra-skeletal examination of OI patients and to preventive measures such as pulmonary exercise or early evaluation for nocturnal hypoxemia.
Additional studies, particularly randomized trials, are necessary to elucidate the ideal combination of treatments and parameters for selecting patients to achieve the greatest benefit from LTAs in CRSwNP.
Therefore, there is a need to elucidate the appropriate combinations of these nutrient sources to obtain financially viable yield of the crop.
It will not only elucidate the super-dominant combination of ACE mixes, but will also uncover subordinate levels which consist of specific emotions, celebrity endorsements and appeal drivers.
Likewise, further studies are needed to elucidate the effect of combination therapy on metabolic syndrome.
Multivariable unconditional logistic regression was used to elucidate the strength and combination of effects on HSV-2 seropositivity as follows.
A large multinational 4-year randomized study, COMBAT [Combination of Avodart® (dutasteride) And Tamsulosin] is underway and is expected to elucidate the effects of combination therapy for patients with symptomatic BPH at high risk of disease progression (Kaplan 2004).
Classification & regression tree (CRT), Kaplan-Meier, and multivariate Cox regression analysis were used to elucidate the significance of the combination of Braf and p300 expression in the diagnosis and prognosis of melanoma.
More studies are underway to evaluate the effects of these compounds on GABA receptors, and to elucidate the effect of the combination of these bioactives on the studied genes, to properly ascertain their clinical relevance in the management of osteoporosis and other related diseases.
