The exact molecular mechanisms need to be elucidated, specifically how GGPP, GGTase II/RabGGTase, and the protein substrate(s) of GGTase can affect tumour cell growth and proliferation.
Interestingly, chow-fed KO mice display isolated hyperglycemia, which may be useful to elucidate pathways specifically related to increased glucose.
Therefore, experiments with AR cells as a negative control will specifically elucidate the AR's effects.
Therefore, in future experiments it will be of great interest to investigate how SSTR and SST expression is regulated in normal human wound healing and chronic wounds and also to specifically elucidate the potential of SSTR antagonists in these wounds.
We specifically elucidate the conflicts arising from an evidence-based versus personalized medicine approach in addressing unmet medical needs in a rare disease such as LN.
In addition, we wanted to more specifically elucidate the functional roles of CA IX, as there is a growing body of evidence showing that they extend far beyond pH regulation.
To further elucidate how CREB specifically regulates subsets of target genes, we performed an integrative computational analysis of the CREB cistrome and fasting-dependent transcriptome in mouse livers to identify genomic features correlated with CREB sites at fasting-responsive genes.
A standard Annexin V affinity assay, frequently used for detection of apoptosis, has been applied to specifically elucidate the exposure of PS by malignant melanoma, soft tissue, prostate, kidney and brain cancer cell lines.
11 18 Since global PPARγ knockout (KO) mice are not viable, 19 and cartilage-specific PPARγ germ-line KO mice exhibit serious growth and developmental defects, 13 14 we created inducible PPARγ KO mice using Col2-rTACre-doxycycline system to bypass the early developmental defects and to specifically elucidate the in vivo role of PPARγ in OA pathophysiology.
