Sentence examples for elongation marks from inspiring English sources

Conversely, c- MYC, a non-SE-associated gene, did not display any loss of elongation marks, consistent with its unreduced expression levels following BRD4 inhibition.

Next, we investigated whether loss of BRD4 and CDK9 from SEs results in reduced levels of elongation marks in gene bodies (GBs) of SE-associated stem cell genes.

BRD4 silencing was sufficient to recapitulate the effects of BET inhibition on the transcriptional elongation of SE-associated stem cell genes and did not affect the levels of elongation marks at c- MYC gene body.

To study whether BRD4 regulates the expression of SE-associated stem cell genes via productive transcriptional elongation, we performed ChIP assays for CDK9, as well as two elongation marks, the phosphorylated Pol II at Ser2 (pS2) and H3K36me3.

However, the elongation marks H3K36me3 and H3K79me3, which are associated with active transcription and resetting of the initial chromatin in human cells [ 33], show moderate positive correlation with transcription in P. falciparum suggesting a new mode of communication between chromatin and transcription [ 34].

Since the function of H2BK5me1 mark was previously unknown and H4K20me1 was known as a transcription elongation mark in mammalian cells [ 30], we speculate that H2BK5me1 may also be a transcription elongation mark.

Since the elongation mark H4K20me1 was present downstream of TSS and so was the proposed elongation mark H2BK5me1, despite being slightly weaker than in expressed genes, it was likely that these genes were actually transcribed but quickly degraded.

Of all the chromatin marks, the elongation mark H3K79me2 and the two acetylations H3K27ac and H3K9ac seem to contribute most to the subprofile variations between the metaclusters.

The promoter proximal peaks common between K562 and GM12878 are enriched for Pol2, the active marks H3K9Ac and H3K27ac, and the transcription elongation mark H3K79me2; this evidence suggests that these regions are actively transcribed promoters.

Cessation and initiation of growth determines the period of active stem elongation, mark the shift between frost resistant and vulnerable phases, and their timing is critical for overall biomass production, fitness and the long-term survival of species [ 3, 4].

To find actively transcribed gene targets bound by MLL-AF4, we identified promoters in RS4 11 cells enriched for both MLL-N and AF4-C as well as H3K79Me2 (an active transcription elongation mark that is highly enriched at important MLL-FP target genes; Krivtsov et al., 2008; Milne et al., 2005) enrichment within the gene body.