Sentence examples for elimination parameters from inspiring English sources

However, each enabling formulation has its limitations and the situation can be further complicated by other absorption distribution metabolism elimination parameters.

All three molecules exhibited linear pharmacokinetics within the dose range tested because area under the curve and maximum concentration (Cmax) increased linearly with increasing dose and a significant difference in the elimination parameters such as clearance or half-life was not observed.

Furthermore, the elimination parameters could not be calculated.

Michaelis-Menten elimination parameters (Vmax = 115 mg/L/hr; Km = 460 mg/L) were selected for input into a semi-physiologic pharmacokinetic model.

This has also been reported in previous studies and was not unexpected, considering the strong biological prior of body weight as a covariate on pharmacokinetic disposition and elimination parameters.

However, DA-9801 did not affect the elimination parameters such as half-life, clearance, or amount excreted in the urine, suggesting that it did not inhibit elimination process of cimetidine, which is governed by OCT1, OCT2, and OAT3.

This analysis was restricted to the two water districts that had the highest levels, to avoid as much as possible the problem of background levels affecting our estimation of the elimination parameter.

The best parameter estimates were obtained with log-transformed data under a mixed-effects model: liver elimination parameter kf = 0.022 days-1 (95% confidence interval [CI] = 0.020, 0.024), and background input rate input = 0.1251 pg/kg/day (95% CI = 0.071, 0.179).

The resulting uncertainty of parameter estimates, after elimination of parameter interdependence, was in the range of the data scatter.

A highly flexible index denominated WQIBA allows the foundation or elimination of parameters in agreement with the needs or restrictions for data acquisition (Bascarón 1979).

Note that the global elimination rate parameters ke and ke0 in eqs 23 and 24, as specified in eqs 62 and 63 (section ), are not plain summations: the rate parameters in individual compartments are weighted by the respective volumes, V i, to scale the contributions to the total elimination according to the size of the compartments.