Elimination of the function of these molecules by knockout or knockdown induces abnormal spindle orientations and affects progenitor population and neuronal formation in mice (Feng and Walsh 2004; Fish et al. 2006), suggesting that proper spindle orientation is critical for neuronal fate decisions.
In some cases, molecular analysis suggests that costs of virulence contribute to the maintenance of genetic polymorphism in the pathogen [ 26]; in yet other cases, elimination of the function of virulence genes seems to be cost-free, suggesting that fitness costs are not universal and depend on the gene or the pathogen considered.
Elimination of the functions of negative regulators of disease resistance frequently results in abnormal plants [37] [39], which suggests that functional balance of the activities of the two types of factors in disease resistance is essential for the normal activity of plants.
The elimination of the functions of such non-hub proteins typically have small effects and so, generally, are not serious.
An HCMV IE1 promoter would give gene expression independent of such evasion and could therefore make latently infected cells vulnerable to immune elimination, independent of the function of the gene being expressed.
Total laryngectomy, with consecutive elimination of the climate function of the nose, might result in functional and structural changes of the lower airways, as described mainly within the first 6 months after surgery [ 13].
The known methods established to overcome the difficulties inherent to the three-part problems are based on the elimination of the entire function P first to obtain a linear system of two singular integral equations for Ψ+and Ψ−.
The aim of the present paper is to establish a new method which is based, conversely, on the elimination of the unknown functions Ψ+ and Ψ− first to obtain a linear integral equation of the first kind for the entire function P, which can be solved rather easily by regularized numerical methods.
The normal method for preparing HpD for injection involves an alkali treatment which causes hydrolysis and elimination of the acetoxy functions, and the only recognized products (haematoporphyrin, hydroxyethylvinyldeuteroporphyrin and protoporphyrin) are inactive in the in vivo assay.
For our opinion for the elimination of the ipsilateral vestibular function by labyrinthectomy, a proper function of the vestibular function of the contralateral side must be provided to exclude the risk of a Dandy syndrome.
Studies performed to assess the contribution of the pronator quadratus to pronation torque of the forearm state that the pronator quadratus is the primary pronating muscle in the forearm [26, 34, 35] and that significant decrease in pronation torque occurs with controlled elimination of the pronator quadratus function [34, 36].
