However, these data contradict the expectation that association of GAPDH with mitochondria would induce elimination of damaged mitochondria; the increased accumulation of mitochondrial proteins may rather reflect a blunted process of elimination of damaged mitochondria.
Elimination of damaged mitochondria by autophagy serves as a rescue mechanism for cells to escape from cell death (Codogno and Meijer, 2005).
Protein acetylation has been recently recognized as a significant approach in controlling autophagic processes such as elimination of damaged organelles or toxic protein aggregates (Banreti et al., 2013).
However, one could postulate that these features are involved in the elimination of damaged hMSCs.
Whereas the elimination of damaged gametes through nvp63-mediated apoptosis may contribute to maintain genome fidelity and stability and thus preserves a key feature of a stem cell, it may as a negative consequence lead to reduced fertility in response to high or chronic genotoxic stress.
HSJ1a did not affect wild-type Parkin-mediated enhancement of the elimination of damaged mitochondria.
The elimination of damaged mitochondria by mitophagy is an important quality control mechanism.
One, the elimination of damaged mitochondria by autophagy would prevent the release of proapoptotic substances from mitochondria, thus preventing apoptosis.
Selective elimination of damaged mitochondria has been observed 82, 83, although the precise mechanisms are still incompletely understood 84.
We show that fitness-based cell selection regulates the elimination of damaged tissue during adult brain regeneration in Drosophila.
