However, each assay specific for a nested transcript, with elimination of expression arising from further upstream, yielded reporter expression.
However, using RNAi, complete elimination of expression of the target gene is rarely obtained.
When aiming to induce hyaline chondrogenic cells directly from dermal fibroblasts, in addition to activation of cartilage-specific matrix genes, elimination of expression of type I collagen is needed for generation of hyaline cartilage.
The most promising potential mechanism responsible for pelvic fin loss in Erpetoichthys is the elimination of expression of transcription factor-encoding genes such as Pitx1 and Hoxd9 in the pelvic region - the mechanism that causes pelvic fin loss in some teleost fishes [ 31, 32, 92].
Using a similar strategy, virulence was also restored to the original transposon insertion mutant (Kim53-K9), confirming that its attenuation resulted from elimination of nlpD expression and not from disruption of pcm expression (Fig. 5C, Table 2; note also that the Kim53Δpcm is as virulent as the wild type strain).
Elimination or enforced expression of certain clustered Hox genes in mouse models has demonstrated profound effects on hematopoietic differentiation and persistent expression of normal or mutated Hox proteins in hematopoietic progenitors can result in leukemia in both mice and humans [1], [2].
This subject was designed to construct a recombinant adenovirus expressing His-tag-ICP47 fusion protein to investigate further the role of ICP47 in the elimination of transgene expression.
For a short while, between the end of imperial censorship with the Kaiser's abdication in 1918 and Hitler's elimination of free expression in the early 1930s, the artists of the Weimar Republic reworked, often brilliantly, our most basic assumptions about how we express ourselves and how we communicate with each other.
It is likely that this module and the 3.0−1.8 module interact to ensure complete elimination of ectopic expression.
The objective of these studies was to study whether elimination of LDLR expression would affect the pathology in AD mice.
