Finally, a significant amount of cisplatin is eliminated in urine [ 8] and this pathway of elimination is dependent on renal output and hydration.
We show that a fast chemical reaction can be treated within the framework of coupled transport equations for heat and mass, after elimination of dependent components.
The preferential type of the mechanism of fiber elimination is dependent on chemical composition and size distribution.
The choice of the stochastic model structure is to allow for an uncertainty in the elimination process dependent on the drug concentration.
Theoretically, nadroparin might even not be the LMWH of choice in patients with reduced renal function, because its relatively small molecular weight renders its elimination mainly dependent on renal function.
A turnover model of G-CSF, where G-CSF elimination was dependent on the circulating neutrophil counts, replaced the feedback function and provided a more mechanistic interpretation which may allow for improved predictive capacity of chemotherapy-induced myelosuppression.
Dalteparin has an average molecular weight of 4000 6000 Da, and the following properties (Dalteparin prescribing information 2006): onset of action: 1 2 hours, duration: >12 hours, half-life elimination (route dependent): 2 5 hours, time to peak, serum: 4 hours, anti-Xa to anti-IIa activity ratio, 2.5.
Adjustment of the dose is required in renal impairment as its elimination is directly dependent on creatinine clearance [ 3].
Carbon dioxide elimination is also dependent on time for gas distribution from the alveolar capillaries up to the fresh gas interface (mean distribution time) [ 21, 22].
Neither elimination rate is dependent on lipophilicity, indicating that the responsible processes are either spontaneous reactions or lipophilicity-independent enzymatic reactions.
