For VEGF in particular, we approximated from Eppler et al.'s compartmental model that distinguished between receptor-specific tissue uptake and non-specific elimination components of plasma clearance [120].
Various PK structural models (i.e., base models) were tested, including different absorption (linear or saturable absorption), protein binding (saturable binding to AAG or the combination of saturable binding to AAG and competitive binding to albumin), and elimination (linear or nonlinear elimination) components.
Based on an efficient genetic manipulation system, improved acarbose production and the elimination of component C in our work paved a way for future rational engineering of the acarbose-producing strains.
There's a clear benefit for Apple from this tech: it potentially allows the elimination of components like the ambient light sensor it removed from the fifth-generation iPod touch.
In this study, we sought to separate the absorption (fa ∗ fg) and elimination (fh) components of bioavailability to study variability of absorption and to investigate the effect of formulations, gastric pH and food on absorption variability.
In cell autonomous elimination, synaptic components may either be (i) recycled, that is, being removed in a functionally intact form for the use at another site, or (ii) degraded.
Although elimination of components of the SWI/SNF complex does not lead to clearly observable effects on transcription, modification of chromatin might still be important for efficient transcription in response to osmostress (Proft and Struhl 2002).
Elimination of this component leads to increase in quantum dots photoluminescence quantum yield.
The decaying DC component elimination is performed using an adaptive digital mimic filter.
In the lowest transmission settings with very high coverage and high initial efficacy of the MSTBV component, elimination is observed even with very low initial efficacies of the other components.
