Culturing mES cells in 2i conditions eliminates differentiation-primed cells from the culture and leads to a robust state of pluripotency that has been termed "ground state pluripotency" and that can be propagated in these growth conditions (Ying et al., 2008; Wray et al., 2010).
In primary rodent OPC cultures, BMP4 by itself almost completely eliminates OPC differentiation and significantly increases the number of astrocytes.
Consistent with the studies mentioned above [ 2, 3, 8, 11], which showed that complete miRNA ablation from ES cells eliminates their differentiation capacity, Marson et al. showed that several FFLs involving miRNAs and ES cell TFs act to regulate ES cell identity and differentiation.
That might eliminate the differentiation that's kept struggling SoundCloud afloat.
Jobs explained with the iPhone 4 that the Retina display's 326ppi was dense enough to eliminate pixel differentiation to the human eye.
Adenoviral delivery of TIEG1 (AdtoEG1) TIEG1−/1−/− cells reversed the RANKL-induced NFATc1 signaling defect in TIEG1−/− precursors and eliminated the differentiation and apoptosis defects.
To our knowledge, this is the first study to show that Oct4 alone is sufficient to eliminate multilineage differentiation of liver CSCs.
The differing distribution of permissive markers serves to prevent DNA sequences from being transcribed as well as to prevent them from being eliminated during differentiation.
To eliminate the osteogenic differentiation effect of Dex, we cultured BMSCs in the absence of Dex and evaluated the osteogenesis of BMSCs.
Taking all these observations together we demonstrate that sequences which become eliminated during macronuclear differentiation are targeted to heterochromatin formation by the introduction of repressive histone modifications.
We then performed qPCR to investigate whether sequences corresponding to MDSs (micronuclear histone h4 gene, actin I, or two loci within mdp2) or to micronucleus-specific sequences eliminated during macronuclear differentiation (MaA81, Stad5, pLJ01) were enriched in the precipitated chromatin.
