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In devising their mathematical model, the researchers systematically sifted through the existing scientific literature on cat-wildlife interactions, eliminated studies in which the sample size was too small or the results too extreme, and then extracted and standardized the findings from the 21 most rigorous studies.
In addition, our criteria eliminated studies examining 'outbreaks' of MDRTB, where a more virulent strain spreads quickly through a community.
Subsequently we eliminated studies describing patients treated with biopsy, neurological status, heterogeneous tumours (and metastases) and heterogeneous treatment.
Second, we read through the articles selected in the first stage, and further eliminated studies based on the exclusion criteria.
We also eliminated studies with non-human subjects, papers written in languages other than English, and articles that only considered demographic or cultural factors.
Although we eliminated studies with a large degree of overlap, some degree of overlap remained among studies included in the meta-analysis, particularly for the morbidity and mortality data for the Japanese atomic-bomb survivors (Shimizu et al. 2010; Yamada et al. 2004).
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Screening sought to eliminate studies that were clearly unrelated to the scope of the project.
An additional limitation is the decision not to eliminate studies that were deemed of poor quality.
Inclusion and exclusion criteria were used to eliminate studies that did not meet the parameters set by the researchers.
Therefore, in order to avoid eliminating studies with important information, we considered HbA1c cut-off within the range of 5% - 8% to be acceptable.
This was intended to eliminate studies with little precision, but thereby also reduced the number of studies included in this meta-analysis because small studies are published relatively frequently.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com