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In cases when circulating biotherapeutic is rapidly eliminated from circulation due to the formation of anti-product antibodies, tissue data may provide useful insight on test article exposure at the site of therapeutic action (or at the site of toxicity).
It is probably the only book ever eliminated from circulation in the U.S. for purely political reasons.
Alternatively, it is possible that an inflammatory response might occur earlier when the virus is actively replicating, and then gets down-regulated by a counter-anti-inflammatory response when the virus is being eliminated from circulation.
NGAL, a 24-kDa protein, is rapidly eliminated from circulation by the kidney.
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Estimation of the glomerular filtration rate (GFR) is essential for the evaluation of patients with kidney disease, and for correct dosage of drugs that are eliminated from the circulation by the kidneys.
RRT does, however, affect antibiotic concentrations as antibiotics are also eliminated from the circulation.
Besides, existing C3NeF needs to be eliminated from the circulation [ 1, 2, 18].
Non-liver-bound peptide in Slc10a1 −/− mice accumulated in the kidneys (Fig. 7B, right panel), where it was eliminated from the circulation.
With a half-life of 3 10 minutes, remifentanil should be almost entirely eliminated from foetal circulation by the time of delivery [ 15].
Unfortunately, they are transiently secreted and rapidly eliminated from blood circulation [ 6, 7] and usually reach a detectable concentration only in advanced stage of the disease [ 8].
Apart from being toxic to healthy tissue, an antibody lacking tumour specificity may be eliminated from the circulation due to immunogenicity, leading to sub-optimal target exposure and decreased therapeutic effect [ 82].
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