Sentence examples for eliminate off from inspiring English sources
Especially the high safety demands and the need to eliminate off target effects in humans require extensive research and development efforts.
Initially we tested SUM159 cells with two shRNA expression vectors (TβRIII-KD and TβRIII-KD4) to eliminate off target effects of the shRNA (Additional file 2: Figure S2).
El Paso said it would sell $2.25 billion in assets, cut capital spending, issue new stock and eliminate off-balance-sheet activities that have raised investors' eyebrows.
These results demonstrate that engineered miR-124 responsiveness can eliminate off-target replication by unattenuated oHSV without compromising oncolytic activity, thereby providing increased safety.
This vector expression was specifically suppressed in hematopoietic lineages and successfully used to eliminate off-target expression of transgenes [13].
JEG-3 cells were transfected with either siLuciferase (siCon) for control or two different sets of GRP78 siRNA duplexes which were used to eliminate off-target effects.
An additional electronic gate was constructed about the diagonal region of a dot plot of pulse area vs pulse height for Hoechst fluorescence emission signals to eliminate off-diagonal events corresponding to doublets and higher order aggregates.
To eliminate off-target effects of PD98059 and saracatinib, constitutively active MEK1 and c-Src were co-transfected with the fgfr2-luc construct in H322c cells, followed by treatment with or without gefitinib for 48 hrs.
In principle, this strategy could be expanded to virtually any relevant cancer phenotype where there is a need for further drug development, although the identification of the molecular target may be needed in order to reduce or eliminate off-target effects at further optimization step following to the initial drug discovery phase.
The two PML siRNAs were used to eliminate off-target effects.
Joint modeling of drugs enables us to eliminate off-target effects and drug-specific experimental noise, leading to a better predictive performance.
