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Our results indicate that for multidomain sequences, sequence comparison results in high error rates, as do heuristics designed specifically to eliminate domain chaining.
A few heuristics to eliminate domain chaining have been proposed (Bjorklund et al., 2005; Huynen and Bork, 1998; Song et al., 2007), but due to the lack of a gold standard, the effectiveness of these approaches could not be evaluated.
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In earlier work we depended on size as a criterion to eliminate domains, but we know now some domains are large and overlap the lower range of sizes of independent proteins [ 28].
Several rules have been implemented to eliminate redundant domains and to resolve conflicting domain predictions such that there is only one domain displayed for any given part of a protein and only one display per protein.
It is short-sighted to eliminate eminent domain as a planning tool.
In such a case, the function often takes extreme values near the boundary: consequently, by adding a virtual point outside of V that takes a still more extreme value, we can eliminate the domain boundary so that we get a function on a manifold without boundary.
Second, when H E = 150 G, much larger than the saturation field, was applied to eliminate magnetic domains, those peaks (at f 0 to f 4 or F 0 to F 4, respectively) still persisted.
In this way, we eliminated the "Domain with Unknown Function" (DUF) domains, because these domains may not be non-enzyme domains.
For the off-diagonal response, the dc bias current is necessary to eliminate transverse domains present in the ribbon.
Fourteen variants showed total splicing disruptions and were predicted to truncate or eliminate essential domains of BRCA2.
Thus, mutations that eliminate certain domains of the protein may still retain developmental functions, and none of the mutations characterized thus far is likely to be null for all gene functions.
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