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Two authors (P.K.B and N.L) independently reviewed the data and assessed the eligibility and methodological quality of each eligible trial.
221 222 223 Design issues such as the number and stringency of eligibility criteria will also directly affect the number of eligible trial participants.
Therefore, eligible trial sites must satisfy several criteria including documented hyper-endemicity and a known epidemiological history of the circulating serotypes.
For each eligible trial, published in the peer-reviewed literature up to the end of 2015, we assessed its risk of bias (internal validity) using the seven-domain Cochrane tool, and its relative pragmatic or explanatory attitude (external validity) using the 10-domain PRECIS tool.
NS extracted key characteristics for each of the potentially eligible trial abstracts.
We independently reviewed each eligible trial for deviation.
Similar(12)
Results: The 17 eligible trials reported data on 2689 participants.
Results: Four eligible trials with a total of 522 participants were identified.
It addresses a specific question and includes recent eligible trials.
The fact that practically all outcomes were only reported by some eligible trials is another limitation.
Literature search was conducted to identify eligible trials indexed from January to December 2013.
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