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Out of the 82 downregulated genes, Ingenuity could map only 35 as eligible for functions or pathways.
It was possible to map 111 out of the 232 dysregulated targets with certainty to the IPA knowledge base: 66 of the mapped genes were eligible for network analysis and 51 were eligible for functions and pathways analysis.
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Of these genes, 3721 were eligible for function and pathway analysis with IPA, which identified transcription and modification of protein as the top functions enriched in the combined gene set (Additional file 1: Table S4).
Among the transcripts up-regulated in the tumour samples, 54 were found eligible for Ingenuity function and pathway analysis.
There is no upper age for participation; however, the responsible clinician will consider if patients are eligible for inclusion (functioning, enable to give written informed consent).
Children whose height was < 1 m at the time of the screening were not eligible for pulmonary function testing (n = 740, 13.4%).
One solution may be perhaps to exclude all those not eligible for immediate function from the study as a study inclusion criterion and randomize after implant stability has been assessed.
To obtain an upper bound for a μ-updated proximity function in each outer iteration in the algorithm, we use the well-known Lemma 3.1, which can be induced from the decreasing part of the kernel function, instead of using theorems which can be obtained from some properties for eligible functions (for example, Theorem 3.2 in [6] and Theorem 5.4 in [20]).
When a 1.5-fold change cut-off was applied, among 173 oligos which passed this additional criterion, 158 genes were eligible for networks and 143 for functions and/or pathways analysis.
It follows from Theorem 5.2 that the iteration bound of the algorithms depends on the parameters β and γ and the upper bound on Ψ 0. Since these are different for different eligible kernel functions, the iteration bounds will also vary.
Individuals with a history of neurological or psychiatric illness or substance abuse, or without a study partner able to corroborate reports of functioning, were not eligible for ADNI; complete eligibility criteria for the ADNI study as a whole are described at http://adni.loni.usc.edu/wp-content/uploads/2010/09/ADNI_GeneralProceduresManual.pdf.pdf
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