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Upon confirmation of eligibility, stage, age and race, if the sampling quota had been met for the specified group, the abstractor was prompted to move on to the next subject.
Standard South African DoH approved ART regimens are used [ 11] (stavudine and lamivudine with either efavirenz or nevirapine in the initial regimen), with standard criteria for ART eligibility (stage 4 disease or CD4 <200 cells/μL).
All Cox regression models were adjusted for the following baseline covariates: age (years), sex, disease duration (years), randomization treatment (conventional versus intensive), prevention cohort (primary versus secondary), and A1C at the study eligibility stage.
A multivariate Cox-regression model was used to estimate hazard ratios (HR) for the treatment outcomes, adjusting (aHR) for the following potential confounders: age, start year ART, gender and ART eligibility stage.
Similar(56)
Survival outcomes were compared with a predecessor study (S9019) with identical eligibility, staging criteria, and treatment, excepting docetaxel consolidationg.
After screening and eligibility stages 16 records remained and were included in the analysis (see PRISMA flow chart in figure 1). 4 Across the 16 papers included in the analysis 1732 requests were made.
Clinical eligibility included stage IIIB with pleural effusion or stage IV NSCLC, measurable disease by Response Evaluation Criteria in Solid Tumors (RECIST), performance status 0 2 by Eastern Cooperative Oncology Group (ECOG) criteria, adequate hematologic, renal and hepatic function.
At this appointment, their eligibility for Stage 2 of the trial is assessed.
Ten studies were then selected to proceed to strict eligibility check stage.
In addition, wide PHQ-9 threshold scores (between 10 and 20/24) meant that relatively few participants were subsequently excluded at the eligibility screening stage.
Of these, 57 met the eligibility criteria; stage IIC-IV, serous or endometrioid subtype, specimens containing ≥ 50% tumor cells and patients receiving platinum-based chemotherapy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com