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She said that as part of its efforts to determine a contractor's eligibility, one of the steps the agency takes is to check its database, the Excluded Parties List System.
Annual prevalence was calculated by dividing the number of prevalent cases identified in the data each year by the number of enrollees 18 years or older during the calendar year who had two years of continuous medical and pharmacy eligibility, one of which spanned the entire calendar year of interest, as well as one day in each of the bordering years.
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Articles were assessed for eligibility if one of the following standard definitions of fluid responsiveness and fluid challenge was adopted: increase in stroke volume (SV) ≥ 10% and/or cardiac output (CO) ≥ 10% and/or cardiac index (CI) [31] ≥ 10% and/or aortic velocity time integral (VTI) ≥ 10% after a fluid challenge [2, 32].
Participants were identified and screened for eligibility by one of two methods.
All patients admitted to the Medical-Surgical Intensive Care Unit of a large Canadian University affiliated teaching hospital were screened for study eligibility into one of three multi-center sepsis trials.
When identified as such, attempts were made to obtain the full text of the article and subsequently reviewed for eligibility by one of the researchers (M. Straetemans).
There were 13 publications [ 15– 27] meeting the specified eligibility criteria, one of which reported extended followup of an earlier study [ 16].
Patients who are deemed appropriate for enrolment into the study will be randomised, following completion of the baseline data collection and confirmation of eligibility, to one of two trial arms control (StanC) or treatment (PREHAB).
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