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Confirmation by autopsy was not required for the eligibility of study subjects since the results of autopsy even when requested, were not included in the death certificate.
Eligibility of study participants was restricted to female BRCA1 or BRCA2 pathogenic mutation carriers who were aged 18 years or older.
Referring to the eligibility of study participants, estimations on the prevalence of goitre might be underestimated because only children attending school were included in the study.
Lastly, in our study, patients with more severe COPD (GOLD 3 and 4) were younger than those with milder disease, which was contrary to our expectation but may be due to the eligibility of study participation or possibly a survivor effect.
No prophylactic mastectomy at recruitment Exclusion criteria: 1. Women from families where a BRCA1/2 mutation has been identified after enrolment 2. Women who cannot provide a blood and urine sample at a local laboratory The recruitment methods are: 1. Prospective Recruitment: Eligibility of study participation is determined at the time of genetic test results disclosure.
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Two reviewers independently determined the eligibility of studies and extracted the data.
Two independent reviewers assessed the eligibility of studies for inclusion, extracted the data, and assessed the quality of the studies.
Two independent reviewers assessed the eligibility of studies for inclusion, extracted the data, and assessed the quality of the methods.
Any issue pertaining to eligibility of studies was solved via discussion with the senior author (H-C.P .. Data were extracted according to tH-C.P .rmation presented in Additional file 1: Table S1 and Additional file 2: Table S2.
The website http://www.crncc.nihr.ac.uk provides the criteria governing eligibility of studies for Network support.
Where uncertainties regarding eligibility of studies occurred, all reviewers participated in the decision about inclusion.
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