Sentence examples for eliciting apoptosis from inspiring English sources

It might thus be hypothesized that TNFα secreted by monocytes acted by an autocrine mode eliciting apoptosis.

In summary, we identified a c-Rel/NFATc2/COX-2 pathway eliciting apoptosis resistance against TRAIL treatment in PDAC that may serve as pharmacologic target.

In the Kasumi-1 stabilized cell line, AML1/ETO expression decreased in the course of incubation in hypoxia, pointing to AML1/ETO suppression as a signal eliciting apoptosis.

However, to date, little attention has been given to develop host-based prophylaxis aimed at selectively eliciting apoptosis in infected cells, perhaps because of early studies demonstrating that infected cells could resist apoptosis.

Aging is generally considered to be the consequence of stem cell attrition caused by the activity of tumor suppressor pathways that censor potentially malignant clones by eliciting apoptosis or senescence.

At the concentration that can block cell cycle progression and DNA synthesis but not elicit apoptosis, these inhibitors potentiate FasL to induce apoptosis.

Strikingly, we also find that a disproportionate number of caspase substrates physically interact, suggesting that these dimeric proteases target protein complexes and networks to elicit apoptosis.

We then asked whether displacement of HK II from mitochondria elicited apoptosis by affecting other pore regulators.

Based on previous results, deregulation of cell cycle markers can elicit apoptosis in post mitotic neurons, which is one of the primary mechanisms leading to cell death in degenerating neurons, including DArgic neurons [23].

Microscopic analysis after DAPI staining indicates that, in the absence of zVAD-fmk, FasL elicited apoptosis in A3 cells as illustrated by strong nuclear condensation and/or fragmentation (Fig. 4B).

To test whether KRIT1 loss correlated with an enhanced cell susceptibility to oxidative stress-induced apoptosis, we compared apoptotic responses of KRIT1−/− and Lv-KRIT1 MEFs challenged with either inorganic or organic oxidants known to elicit apoptosis, including H2O2 and tert-butyl hydroperoxide (TBHP) [77], [79].