Accelerating the aggregation of mutant httex1 with scFv-6E intrabody elicited a further increase in PI-staining (Fig. 7B, C), particularly among cells exhibiting large or numerous inclusions as indicated by a prominent forward shift in GFP fluorescence intensity (103 104 AFU, Fig. 7A, see arrows) within these cells.
As with the rhodamine dyes, N-alkylation elicits a further bathochromic shift.
This would elicit a further additive effect, by slowing pyruvate entry into the cell and cause a further drop in kPL in DCA-treated cells.
When 10-NCP was added to ShhN-treated neurons, it elicited a further LC3-IILC3-IIase (Fig. 1D, lane 1 and 2; supplementary material Fig. S1A,D).
This analysis clearly revealed that treatment of the cells with identical concentrations of the drug in its encapsulated form elicited a further significant enhancement of its activity.
Higher percentage of serum samples of men from Qaanaaq and Sisimiut elicited a further increase of the TCDD induced AhR activity (Table 3, Fig. 1C).
In offspring from LS-fed maternal flies, an HS diet (LS-HS) elicited a further reduction in weight and glucose (Fig. 3A,B) and an increase in trehalose, glycogen and TAG as compared with LS-LS flies (Fig. 3C E).
Concentrations of 100 μg/ml aSNP displayed a similar effect compared to 4-h exposure (76 ± 13 vs. 73 ± 9.9 %), whereas 300 μg/ml aSNP elicited a further decline in viability (28 ± 8.8 %).
Sale et al. (2011) demonstrated that BA, but not SB, significantly delayed time to exhaustion in the 110 % CCT test (i.e. cycling capacity test at 110 % of the maximum power); the addition of SB to BA elicited a further nonsignificant improvement in performance.
The 10 mg/kg MPD dose elicited a significantly further augmentation (p < 0.01) as compared to the 2.5 mg/kg dose in both of these locomotor indices (horizontal activity [F1,15 = 117.77, p = 0.00]; vertical activity [F1,15 = 126, p = 0.00]) on experimental day 2 when compared to day 1, on which the rats received saline.
