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OVA elicited marked neutrophil-predominant inflammatory cell infiltration in the eyes.
Withaferin-A elicited marked apoptosis and vimentin cleavage in vimentin-expressing tumor cells but significantly less in normal mesenchymal cells.
This hormone elicited marked increases in bone formation and increased numbers of mature osteoblasts, which express high levels of potential anti-tumor factors that include decorin, lumican, and CYR61.
Both fasting and insulin neutralization elicited marked upregulation of PDK4.
From a mechanistic point of view, PR elicited marked inhibitory activity in soybean lipoxygenase assay.
In addition, omeprazole elicited marked improvements in the domains of anxiety, depression, and self-control[ 17].
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Proof-of-principle experimental studies utilizing knockin mice have also demonstrated that transgenic overexpression of the cardiac creatine transporter or the muscle CK isoform CKM can elicit marked protection against stress-induced heart injury.
Treatment with the same concentrations of As2O3 or berberine did not elicit marked cytotoxic effects on U-87 cells.
We found that heat-killed mycobacteria can elicit marked γδ T-cell responses, suggesting there are alternate mechanisms of activation that have yet to be reported.
Interestingly, we noted that FAC in combination with U0126 led to a marked increase in lysosome numbers compared with either FAC or U0126 alone (together with increased calcein AM localization to lysosomes), in contrast to T80, which did not elicit marked changes in lysosome numbers upon cotreatment with U0126 (Supplementary Figure 7).
We demonstrate that doxorubicin-tethered gold nanoparticles via a poly ethylene glycol) spacer and an acid-labile hydrazone bond mediate potent doxorubicin delivery to breast CSCs, which reduces their mammosphere formation capacity and their cancer initiation activity, eliciting marked enhancement in tumor growth inhibition in murine models.
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