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Monoclonal antibodies and drugs designed to elicit this effect typically bind cell-surface epitopes that are overexpressed on target cells but also present on other cells.
Although no single treatment was effective by itself, the combination of 5-AzaC followed by TSA was sufficient to induce the endogenous expression of Mbp, Mag, Cnpase and Cgt in fibroblasts, whereas treatment with 5-AzaC and sirtinol was able to elicit this effect only for Cnpase expression (Figure 4A D).
The inhibitor did not elicit this effect in MDA-MB-231-34 cells.
The capacity of tumour cells to elicit this effect varies form tumour to tumour.
Surprisingly, SMC3 depletion appears to elicit this effect indirectly by rapidly decreasing ESR1 transcription and ERα protein levels.
The minimum BPA dose required to elicit this effect is within the range of dose levels believed, until now, to have little or no significant biologic impact, even under conditions of long-term BPA exposure.
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However, the mechanism by which EE elicits this effect is unclear.
Recently we have identified new and simpler conditions for inducing capsule enlargement that consistently elicited this effect.
This effect apparently required interaction between the light- and temperature-dependent entrainment mechanisms, because it produced an increase in activity at a time of day when neither light nor temperature elicited this effect on their own (see also wild-type data in Figure 3; data not shown).
Our findings demonstrate that doping of WC nanoparticles with Co markedly increases their cytotoxic effect and that the presence of WC-Co in particulate form is essential to elicit this combinatorial effect.
27 28 29 Bradykinin seems to elicit this bradycardiac effect by centrally controlling the baroreflex heart rate.
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