The spike train elicited stable postsynaptic responses, which drastically increased to 400 to 500% of control values during periods of place field activity (n = 5, Figure 1C to E, red circles denote place field responses).
Critically, this is a task that patients with brain damage can perform reliably (Price and Friston, 1999), eliciting stable response times with low error rates (Tyler, 1992).
These results show that a transient GATA4-mCherry input elicits stable expression of one of two mutually exclusive expression programs, suggesting the system behaves as an irreversible switch with two stable states.
The single stimulus reflex threshold (RT-SS) was the lowest intensity (mA) needed to elicit a stable muscular response.
The reflex threshold following a single stimulus (RT-SS) was considered as the lowest current intensity needed to elicit a stable electromyografic response (mA) (see ref. [8]).
We deliberately presented this exercise up front to elicit more stable values from participants.
However, we found that testing with the above non-random reward regimen is preferable, since it elicited highly stable performance even when the testing blocks were up to 1000 trials long (data not shown).
Rings that did not elicit adequate and stable contraction to high K+ were considered as damaged and discarded.
Rings that did not elicit adequate and stable contraction to high K+ were considered as being damaged and omitted from the study.
Rings that did not elicit adequate and stable contraction to high K+ were considered to be damaged and omitted from the study.
