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However, the approach is technically challenging and can elicit severe toxicity in patients.
These Klebsiella strains are resistant to multiple antibiotics, tend to colonize when intestinal microbiota is dysbiotic, and elicit severe gut inflammation in the context of a genetically susceptible host.
Current FDA-approved chemotherapeutic antimetabolites elicit severe side effects that warrant their improvement; therefore, we designed compounds with mechanisms of action focusing on inhibiting DNA replication rather than targeting multiple pathways.
Though corneal epithelial injury usually does not elicit severe inflammatory cell infiltration in the wounding areas, it induces mild inflammatory cytokine responses [22], [24], [25].
Yet, it is activated by corneal epithelial debridement injury, which affects predominantly the surface epithelial cells, but has little influences on the underneath stroma and does not elicit severe inflammation due to the immune privileged nature of the cornea [41].
They find that excess dietary sugars, but not fats or proteins, elicit severe insulin-resistant phenotypes.
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As PLK1 and AuroraB are crucial regulators of cell division that are often overexpressed in several cancers and whose inhibition elicits severe stress responses such as senescence and apoptosis induction, we determined their involvement in BI-D1870-mediated BI-D1870-mediated BI-D1870-mediated
Adoptive transfer of naYve CD4+CD45RBhi T cells isolated from either B6 WT or B6.TLR2 /– mice elicited severe colitis in B6.RAG /– recipients, with no significant differences in either severity or incidence of disease (Fig. 2C).
The article, Mr. Rahman wrote in the letter dismissing Mr. Sehbai, "was perceived to be damaging to our national interest and elicited severe reaction of the government".
Russia and China in early February vetoed a UN Security Council resolution that would have spelled out a timetable for regime change in Damascus, eliciting severe criticism from the United States.
Further, our previous study showed that TGFβ1 activates NF-κB (Li et al., 2004b) and elicits severe inflammation in oral mucosa (Lu et al., 2004).
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