"Addressing these concerns will be more difficult for the committee and the professional society," Clark reflected, "because standards for employment policies typically elicit sensitivities regarding resource allocations and institutional change.
All together these results indicate that Pin1 is crucial in maintaining the self-renewal and replicative potential of both normal stem cells and CSCs of the mammary gland and that genetic or pharmacological ablation of Pin1 impairs their expansion with a strong effect in CSCs, eliciting sensitivity to chemotherapeutic drugs.
The acquisition of MDR resulted in increased reliance on a single protein/pathway, and that reliance was exploited with inhibitors to elicit collateral sensitivity in those cells.
The cells were then assessed against 37 other cytotoxins of varying mechanisms, of which nine were found to elicit collateral sensitivity, with two being DNA-damaging agents (cisplatin, bleomycin) and six being antimetabolites (vidarabine, acicivin, cytarabine, 5-fluorouracil, tegafur, tiazofurin).
This may be attributed to the fact that A431 cells express high EGFR levels to elicit high sensitivity, whereas K562 and P388 cells do not express EGFR thereby conferring inherent resistance to gefitinib.
In addition to transporter inhibition, MRP1-mediated resistance can be overcome by MDR-selective compounds because the expression of MRP1 has also been shown to elicit collateral sensitivity of multidrug-resistant cells.
Deficiency of only one of these proteins was not sufficient to elicit TRAIL sensitivity, demonstrating that in non-transformed cells multiple pathways control TRAIL resistance and they act in a redundant manner.
Long tucked away behind the mountains of northwest Iran, Lake Urmia is becoming a national symbol of environmental degradation that is eliciting public sensitivity and awareness.
Injection of RNA transcribed in vitro from this clone into Xenopus oocytes elicits serotonin sensitivity.
A stated preference survey was used to elicit visitor sensitivities to a series of management and experiential conditions, while simulation was applied to predict mode choice as a consequence of various access policies.
