In addition to eliciting prominent short-term dynamics, the delivery of place-field associated spike trains on a longer timescale led to robust potentiation of mossy fiber synaptic responses.
As shown above, the four endoperoxides elicited prominent in vitro anticancer effects through regulation of cellular ROS environment.
As shown in Figure 1, the domR construct elicits prominent phenotypic effects when driven in the wing, head, notum, and legs compared to the controls expressing GAL4 alone.
However, following the transition to hypokalaemic conditions, spontaneously beating preparations elicited prominent EADs and triggered beats that preceded episodes of non-sustained VT (n = 6; Fig. 1b).
The present study accordingly used a recently established murine whole heart model of arrhythmogensis (Killeen et al. 2007), which elicits prominent EADs, triggered activity and VT in the setting of AP prolongation.
Thus the 2-DE and Western blotting data revealed that the early stage of DM elicits prominent tyrosine nitration of four renal cortical proteins, and that treatment with enalapril prevents or diminishes tyrosine nitration of three of these proteins.
The TSA-responsive Clusters A-C at 6h (Additional file 1: Figure S1) or 24 h (Additional file 2: Figure S2) elicited prominent TNF-α, HNF-4A, IFNγ YY1, Egr1, E2F, and TP53 specific nodes that are connected to gene networks involved in metabolic regulation, cellular energetics and proliferation and apoptosis (SLP1, SPP1, and DDX5).
Interestingly, these same equivalent concentrations of ATR (10 µM) elicit a prominent effect on aromatase reporter activation, similar to activation observed by either EGF (50 ng/l) or forskolin (1 µM, Fig S2A).
When human melanoma cells are injected into nude mice they usually give rise to tumours that grow progressively and do not elicit a prominent host response.
A further relevant feature was the observation that membrane immunization, eliciting a prominent humoral immune reaction, conditioned the recipients so that they subsequently failed to elicit a tumour rejection immunity on treatment with irradiated tumour cells.
