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The 5HT1a and 5HT1d receptors are autoreceptors and agonism here has been demonstrated to decrease net serotonergic transmission.[ 4] m-CPP has been reported to elicit craving for alcohol and feelings similar to intoxication in abstinent alcoholics [ 5, 6]).
Drug-associated cues elicit craving and relapse in addicts (Childress et al, 1986; Foltin and Haney, 2000), and disruption of drug cue associations would therefore limit relapse susceptibility.
The reasons for the discrepancies are likely to be multiple including heterogeneity of cocaine abusing populations, methods used to elicit craving and the period during the menstrual cycle when the measurements were done.
Similarly the fast DA increases as triggered by conditioned cues [10], [11] are linked with craving responses in cocaine abusers [14], [15] whereas a similar magnitude of DA increases but achieved slowly (as induced by oral administration of MP) do not elicit craving [16].
The discrepancies between our findings of decreases in limbic metabolism and prior imaging studies showing limbic activation with cues exposures are also likely to reflect the sensitivity of brain responses to the mechanisms used to elicit craving (and as importantly the control condition used to compare this) and to the imaging methods used to measure them (fMRI, PET-CBF, PET-metabolism).
It should be noted, however, that the findings of Potenza et al. [ 12, 13] are difficult to interpret because of the complex emotional movies used to elicit craving for gambling.
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The first objective of the present research was to replicate previous reports that exposure to food cues elicits craving for food.
Consistent with this hypothesis, Kavanagh et al. (2005) reviewed evidence that concrete imagery is an important component of craving, that imagery elicits craving, and that unrelated imagery tasks reduce craving.
The results suggested that food cues reliably elicited craving, increased attention to the cues, and decreased positive affect in both samples, although reactivity was greater among the sample with greater eating pathology.
Furthermore, in a preliminary treatment trial in which DCS was used to enhance extinction of a cocaine-associated memory (Price et al., 2013), the DCS-treated group of cocaine abusers subsequently showed an increase, not a decrease, in craving elicited by later exposure to the CS.
In summary, processing visual food stimuli and comparing oneself to other slim women elicits more anxiety, but not craving, in women with BN compared to HCs.
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