This is problematic where biologicals elicit antibody responses that compromise efficacy and result in hypersensitivity exemplified by serum sickness, wherein a systemic hypersensitivity reaction develops against heterologous serum proteins, as may occur with serum therapy (i.e., passive immunization using serum antibodies).
We observed that a single oscillation cycle during the hour-16 to hour-18 period was insufficient to enhance the phenotype, suggesting that multiple cycles are necessary to elicit the stress that compromises the integrity of gonad morphogenesis in the absence of mir-34 and mir-83.
In fact, in PP2A mutants, we observe an enhanced fusion growth defect, suggesting that disruption of PP2A causes cellular stress, which elicits, rather than compromises, Pol III repression.
The results and the modification strategy illustrate a concept for designing prospective biomaterial surfaces such that the manipulation employed to elicit targeted biological responses does not compromise immunological compatibility.
Different drug therapies may elicit unwanted side-effects, which could compromise the patients' HRQL, and adherence with the treatment.
Overall, our findings suggest that associative effects based on previous experience with the experimental situation can compromise the eating inhibition elicited by i3vt administered insulin.
Ethanol has been shown to elicit a number of pathophysiological responses including compromised glucose transport and gastric acid secretion via an AMPK-dependent manner [29], [30], similar to our current finding.
Our current study provided a particularly interesting observation that the exposure to nicotine appears to compromise the activation of G1/S checkpoints elicited by γ-irradiation or BP treatment, but not to G2/M checkpoints.
Interestingly, the serum of these patients contains auto-antibodies to the NMDA receptors [42], and these elicit cognitive impairment in mice that received lipopolysaccharide to compromise the blood brain barrier integrity [42].
Thus, fungal cells have evolved mechanisms to elicit adequate adaptive responses when cell wall integrity (CWI) is compromised.
