Once, with his customary elevation of tone, Ed Balls, the shadow chancellor, called the idea of Labour ruling out an in/out referendum on the EU "stupid".
He wrote: "Ed Balls, with his customary elevation of tone, once called the idea of Labour ruling out now an in/out referendum on the EU 'stupid'stupid
Henceforth he would produce a different kind of poetry, defined by a new sobriety, a new restraint, and a lofty, almost Miltonic elevation of tone and diction.
We demonstrate that D1 dopamine receptor (Drd1) signaling within the SCN is necessary for properly timed resynchronization of activity rhythms to phase-shifted light:dark cycles and that elevation of DA tone through selective activation of VTA DA neurons accelerates photoentrainment.
Results from animal studies indicate that a sustained elevation of SNS tone stimulates smooth muscle cell hypertrophy [ 103].
A striking elevation of sympathetic tone is present in COPD and might provide a link between COPD and systemic effects, specifically cardiovascular disease [ 10- 14].
According to these considerations, a statistically significant weight increase was found when aripiprazole was combined with high serotonergic antidepressants [ 72], possibly due to the elevation of serotonin tone by these latter compounds.
Second, CPAP in patients with CHF, especially in those with concomitant obstructive sleep apnea, will exert much of its beneficial effects by reducing the elevation of sympathetic tone, thus affecting autonomic function rather than ventricular loading.
However, elevation of DA tone can lead to DUO period lengthening, which either results in DUO free-run (for example, Figure 7D,G) or reinstatement of oscillator synchrony albeit at a different harmonic.
Conversely, significant increases in burst rates, which often followed prolonged elevations of cholinergic tone, were often associated with reduced BI values.
Strikingly, this manipulation did not reduce the amplitude of dopaminergic oIPSCs (1.3 ± 0.3 nA, n = 12; p>0.05 vs ACSF, p<0.01 vs GAT antagonists, Dunn's Multiple Comparison Test; Figure 8A,B), indicating that the reduction in oIPSC amplitude observed following GAT inhibition is not secondary to elevation of ambient GABAergic tone.
