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One patient (implanted in dorsal cortex of IC) even experienced complete loudness decay and elevation of thresholds with daily stimulation.
The smaller elevation of thresholds in the static Small Mask condition might be due to the weaker integration of the grating components into a plaid.
The second is that the congruency of gender did influence adaptation, with greater elevation of thresholds occurring in the different-gender than the same-gender condition, even though we had controlled for perceptual similarity.
If decreased contrast discrimination thresholds with large masks are indeed associated with perceptual segmentation of Test and Large Mask components, as suggested from Expt. 2, then any elevation of thresholds, such as that previously observed with moving stimuli with small masks, might conversely result from enhanced perceptual integration of the components into a plaid pattern.
However, it is unclear why the obtained curve displays a "double bump" aspect with an elevation of thresholds at 10000 Hz (12.7% or 126° of cochlear length) and 3000 Hz (29.7% or 294° of cochlear length).
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On inspection, only the condition with the higher-contrast mask and a different pattern appears to show a clear elevation of threshold.
To determine the effects of selective reduction in sodium current, we applied tetrodotoxin to papillary muscle from healthy rats and found reduction in action potential amplitude and rate of rise, as well as elevation of threshold.
After intrathecal administration of BQ-123, elevated trends of mechanical thresholds were seen in all BQ-123 drug groups as shown in Figures 1, 2, and 3. BQ-123 at dose of 15 μg induced slight elevation of threshold when compared to the control group 30 minutes and 1 hour after intrathecal administration of BQ-123 on day 4 to day 6, but the results were not statistically significant.
Results: Significant elevations of thresholds, comfortable levels, and dynamic range were found during the first few months of implant use.
Obvious elevation of the thresholds following morphine, compared to the consistent thresholds in saline treatment, validated the described technique for the study of antinociception in awake dogs.
However, further studies are still needed to reduce fibrous encapsulation of the microelectrode array, which resulted in a gradual elevation of current thresholds to elicit EEPs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com