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Tumor cells transfected by DPS complexes containing p53 gene displayed almost 50% higher suppression in proliferation compared to those untreated cells, accompanied with a 46% elevation in the number of cells at sub-G1 phase and remarkable p53 dependent cell cycle perturbations prior to apoptosis.
There was a slight elevation in the number of eosinophils (8.0%, normal range 1.0 5.0%) and creatine kinase level (1.35 mg/dl, normal range 0.6 1.2).
Furthermore, all tested drugs caused elevation in the number of bone marrow (BM) cells; however, splenocyte count was significantly decreased post Para and Ibu administration, but Diclo treatment showed increase in splenocyte count.
In addition, these animals demonstrate approximately threefold elevation in the number of activated p38 MAPK-positive cells in the brain [58].
For the same parameter values, however, a transient elevation in the number of pathogenic bacteria that leads to translocation across the epithelial barrier stimulates an inflammatory response.
Red alerts (indicating a significant elevation in the number of influenza-coded visits in the system) were seen at the beginning of the influenza season as well as during the emergence of pandemic H1N1 2009 in late April/early May.
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The IL-1ra treatment induced significant elevations in the number of BDNF-expressing cells in both WT and Tg2576 mice (F (1,18)=5.803, P<0.05) (Figure 6f).
As part of the inflammatory response during sepsis, there are elevations in the number of myeloid-derived suppressor cells (MDSCs).
The elevations in the number of errors found in relation to noise exposure were small and the clinical significance of such minor changes is difficult to determine.
To determine if increased adherence was due to elevations in the number of circulating leukocyte in mice fed WD, whole blood samples were evaluated for leukocyte content.
DOI: http://dx.doi.org/10.7554/eLife.01964.008 The observed expansion of MkPs in miR-142 mutants was further supported by a concordant elevation in the numbers of CD41+/CD42+ miR-142−/− MKs relative to WT controls.
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