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Analysis of these T cell subsets based on Foxp3 expression in CD4+CD25+CCR4+ cells demonstrated a significant elevation in the frequency of CD4+CD25+CCR4+Foxp3− T cells in the total PBMCs in HAM/TSP patients (n = 11) as compared to that in HDs (n = 8) (left panel, Figure 3A; p = 0.001).
Formaldehyde induced a subtle but significant elevation in the frequency of the mwh clones (Table 1).
In contrast to the reduction in UV-induced crossovers, we observed an elevation in the frequency of spontaneous crossovers in the exo1 strain relative to the wild type.
Of note, we found no evidence for an elevation in the frequency of Foxp3+ donor Tg4 cells, nor in IL-10 production in response to PIT.
However, despite this absence of a transient elevation in the frequency of dividing cells, CaMKK ssp1 mutant cells had reduced their length at division 2 hr after the stress.
Treatment of mice with different concentrations of DXR (5, 10, or 15 mg.kg-1 body weight) resulted in a dose dependent elevation in the frequency of micronucleated polychromatic and normochromatic erythrocytes in mouse bone marrow, and it was accompanied by a DXR dose dependent decline in the PCE/NCE ratio.
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Moreover, the genotype of patients in the PsA cohort was shown to be heterogeneous with significant elevations in the frequency of haplotypes containing HLA-B*08, HLA-C*06:02, HLA-B*27, HLA-B*38 and HLA-B*39.
The increase in the life span of populations in the Western world has been accompanied by an elevation in the frequencies of neurodegenerative diseases, e.g., Alzheimer's and Parkinson's diseases.
The authors observed no indication of damage and found no elevation in the frequencies of sister chromatid exchanges (SCEs) or the concentration of 8-hydroxy-2′-deoxyguanosine in leukocytes.
We saw no PIT-driven elevation in the frequencies of Foxp3+ cells amongst the donor cells, although PIT-exposed PD-1−/− donor cells showed elevated numbers of Foxp3+ cells as a reflection of their elevated total numbers.
A recent study transgenically expressed autoantigen on all DC subsets and found PD-1-dependent elevation in the frequencies of autoreactive Foxp3+ T cells as a result (Yogev et al., 2012).
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