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Here, we found that treatment with Rib elevated the RAGE expression in astrocytoma cells, and the elevation in the expression of RAGE correlated with the elevation of cellular AGE level.
Taken together, our results potentially indicate that a meniscal injury results in a significant elevation in the expression of the inflammatory mediators TNF-alpha and IL-6 locally at the site of injury, and of IL-6, in the synovium in close proximity to the injury.
Elevation in the expression of glial fibrillary acidic protein (GFAP) has been used to demonstrate an increase in activated astrocytes.
However, in H. pylori-induced atrophic gastritis there was a marked elevation in the expression of iNOS compared to uncomplicated gastritis.
A marginal elevation in the expression of Hsp27 and Hsp70 observed in Figure 1B was not significantly different between the two ages or between the two genotypes (p>0.05, two-sample t-test).
Interestingly, the skin of SKO mice displayed a 27.7-fold elevation in the expression of Lcn2 (Table 12), which has previously been shown to be a retinoic acid-induced gene linked to sebocyte apoptosis in human SEB-1 cells [57].
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STZ resulted in diabetic neuropathy with hyperglycemia and a lower paw withdrawal threshold (PWT), accompanied by elevations in the expression of the NADPH oxidase subunits p47phox and gp91phox and in the levels of hydrogen peroxide (H2O2) and malondialdehyde (MDA) and a reduction in superoxide dismutase (SOD) activity (P < 0.05) in the spinal cord.
In contrast, no to marginal elevations in the expression of all neutrophil chemokine-encoding genes were found in M. avium-resistant I/St mice throughout the observation period, which corresponds to a well-controlled inflammatory response.
A TNF-neutralizing antibody effectively blocked Cd-induced elevations in the expression of these genes.
Elevations in the expression of several IAPs occur as a frequent and early event in the etiology of prostate cancer.
Activation of AMPK with the use of the AMP-analogue AICAR has been associated with elevations in the expression of PGC-1α, mitochondrial proteins and higher mitochondrial enzyme activities [ 8, 9, 23].
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