Exact(8)
Consequently, culling selects for elevated virulence.
Movement away from this optimum towards further elevated virulence would generate a greater reduction in the infectiousness duration than in the transmission rate, while movement towards lower virulence would cause a greater decrease in the transmission rate than in the infectiousness duration (Figure 7a).
In a clinical perspective, urease-positive phenotype is considered for elevated virulence in V. parahaemolyticus [ 40].
To date, nine genes responsible for the elevated virulence of race T have been identified.
146, 152– 154 Consistent with USA300's global dominance, laboratory experiments show elevated virulence of this strain compared to contemporary MRSA isolates.
Except for the bm2 mutant, all other single bm mutants displayed elevated virulence symptoms after U. maydis infection, with bm3 showing the strongest effect.
Similar(52)
Thus, increased culling selects for elevated influenza virulence.
Our analysis shows that a control strategy that is epidemiologically beneficial can have detrimental evolutionary repercussions in terms of reducing long-term resistance to H5N1, increasing host mortality, and selecting for elevated influenza virulence.
Many pathogenic bacteria sense elevated temperatures (37°C) and turn on virulence and metabolic genes appropriate for survival and growth within the host.
This, in combination with the ability of elevated CO2 to enhance bacterial and fungal virulence and survival, suggests that hypercapnia may predispose humans to infections or worsen outcomes [ 3].
In contrast, infection by the mutant strain, which is attenuated for virulence, is associated with significantly elevated expression and activation of host genes involved in host protective immunity networks/pathways.
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