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Caquet et al. (2001) showed that water temperature, pH, dissolved oxygen and suspended solids exhibited a very low variability between replicate mesocosms whereas nutrients displayed elevated variability.
In this dataset, only 12 genes are deemed significantly DV and all of these genes have elevated variability and average expression level in DMD patients.
Of note, this elevated variability is unrelated to within-breast variability.
A hypothesis was advanced that the elevated variability in disease-related categories may be a function of higher expression also observed in these categories.
It has been proposed that the elevated variability observed in captivity [4] stems from maladaptive adjustments to the laboratory environment shown by rodents [5].
An alternative (hypothesis 2) calls for elevated variability to be a hallmark of a gene's disease-relatedness, but no direct role in pathological mechanism can be attributed.
Similar(49)
Hyperglycemia, elevated glycemic variability and hypoglycemia, were associated with an increased mortality risk in critically ill patients [4 6].
Likewise, edge plots had sharply elevated spatial variability in overall tree-community change (F18,20 = 17.76, P<0.0001), floristic trajectories 1 and 2 (both F18,20>9.08, P<0.0001), the abundance of pioneer and invasive trees (F32,32 = 11.59, P<0.00001), and tree-species turnover (F18,20 = 15.25, P<0.0001), relative to forest interiors (all F-tests comparing variances in edge vs. interior plots).
Cheung et al. (2003) showed that genes of certain functional classes have elevated expression variability in human lymphoblastoid cells.
Elevated QT variability index has also been described in 47% of persons with chronic kidney disease and is associated with diabetes and baseline coronary artery disease [ 42].
4 6 As a result, two multicentre studies were stopped prematurely because of a high incidence of hypoglycaemia. 4 5 Apart from hyperglycaemia and hypoglycaemia, elevated glucose variability has also been shown to be related to adverse outcomes.
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