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The elevated turnover was suggested to be caused by a reduced attachment of the E-cadherin complex with the actin cytoskeleton in Rac1(12 -expressing PANC-12 -expressing
With regard to the current knowledge, one can speculate that this reduction is likely a consequence of decreased protein half life time of E-cadherin due to an elevated turnover of E-cadherin/catenin complexes [ 50].
These phenotypes are due to increased PA levels resulting from elevated turnover of PC, catalyzed by the SPO14 -encoded phospholipase D (Sreenivas et al. 1998; Xie et al. 1998).
As recently reported [ 19], we noticed that herds characterised by an elevated turnover of cows showed many sub-types of Map (i.e. herds no. 31, 32 and 33), which differed each other for both Mini-and Microsatellite loci (Additional File 2, Table S2).
Based on our turnover data, we speculate that the elevated turnover of K36me2 in H3.2 is essential for maintaining this PTM at a low level, and that it is the absence of K36me2 on H3.2 rather than its presence on H3.3 that is crucial for epigenetic function.
Another reason for a decrease in DCP could be an increased recruitment and elevated turnover of circulating DCP in chronically inflamed tissues all over the body including the vessel wall.
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We conclude that whole body amino acid flux is increased due to an elevated protein turnover rate.
Increased levels of CK-18 fragments indicating elevated apoptotic turnover in critically ill patients was first described by Roth and colleagues [ 14].
The reality of cold-induced protein denaturation is well illustrated by the observation of elevated protein turnover in Antarctic fishes via ubiquitin-mediated proteasomal degradation (Todgham et al., 2007).
Because an elevated cell-turnover rate in the colon epithelium could in part explain the formation of the mass lesions, a bromodeoxyuracil (BrdU -incorporation study was conducted.
In fact, elegant studies by Jackowski [25], [26] revealed that the accumulation of new phospholipids for dividing cells is the product of elevated synthesis and turnover that occurs during G1 and early S phases.
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