Sentence examples similar to elevated somatic mutations from inspiring English sources

Significantly mutated genes (SMGs) were defined as the somatic mutations with higher mutated frequency than background mutation rate.

Similarly germline mutations in PTEN confer an elevated risk of breast cancer in individuals with Cowden's disease, but somatic mutations in PTEN are rarely observed in breast cancers outside this context (Rhei et al, 1997; Sakurada et al, 1997).

The contaminating stromal cells may interfere with the ability to call somatic mutations, especially in the low-grade foci, leading to a falsely elevated number of apparently private mutations and obscuring the clonal relationship among concurrent foci.

Accordingly, the signature of positive selection, namely, an elevated non-synonymous/synonymous substitution ratio [ 27, 35], is expected to be detectable among somatic mutations even in the presence of some contamination by sequencing errors and SNPs.

Private somatic CNVs occurred more frequently than private somatic mutations.

Somatic mutations identified from enrolled patients.

Detecting Somatic Mutations in Normal Cells.

Four hundred twenty-six genes had recurrent somatic mutations.

We identified somatic mutations in memory-type36 CD8+ T cells.

Next, we analyzed somatic mutations in 29 SCCs.

Pathway alterations include homozygous deletions, focal amplifications and somatic mutations.