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Moreover, elevated PRH levels influence T-cell proliferation in mouse transgenic experiments where the expression of Prh is under the control of T-cell-specific promoters in the bone marrow and the thymus [ 69].
In contrast, elevated PRH expression activates expression of the embryonic SMemb/NMHC-B gene in adult VSMCs.
Elevated PRH levels can lead to the disruption of PML nuclear bodies, the inhibition of the eIF-4E-mediated transport of cyclin D1 mRNA and a subsequent reduction of cyclin D1 protein levels [ 20].
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