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Cultures in rotating wall vessel bioreactors and orbital shake flasks with intermittent shaking both resulted in an elevated multiplication of cells expressing the surface marker CD34+ that labels hematopoietic stem and progenitor cells (HSPCs)—compared to static cultures51, 52.
The hypoxia induced by the elevated multiplication and metabolism of cancerous and precancerous cells therefore results in an extended phenotype that encompasses angiogenesis of normal cells in the vicinity.
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This repeat harbours the blaA gene and at least part of the PhiYep-1 prophage, indicating a possible link between PhiYep-1 tandem multiplication and elevated ampicillin resistance.
These results demonstrate that Rep1 regulates human SNCA expression by enhancing its transcription in the adult nervous system and suggest that homozygosity for the expanded Rep1 allele may mimic locus multiplication, thereby elevating PD risk.
Given that multiplications of SNCA have been implicated in heritable PD, where elevated dosage increases penetrance and lowers age-of-onset, we hypothesized that a subtle increase in SNCA expression over decades confers an elevated risk for late-onset, sporadic PD.
Slovenia is mostly elevated.
The situation is "elevated".
Elevated Focused.
Elevated anxiety?
Keep your feet elevated.
Keep your wrists elevated.
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