Sentence examples for elevated insulin sensitivity from inspiring English sources

Further, we found a major reduction of inhibitory Ser phosphorylation of IRS-1 seen exclusively in GHRKO muscle which may underpin their elevated insulin sensitivity.

Our mutants were clearly resistant to age-related obesity, notably exhibiting elevated insulin sensitivity, which reminds the metabolic features of some long-lived mutant mouse strains (Bartke & Westbrook, 2012).

In this study, the authors tested the hypothesis that the modest effect of caloric restriction on longevity of GHR KO mouse is because of the failure of caloric restriction to further increase the already maximally elevated insulin sensitivity in this mouse model.

We demonstrate that a shift from the secretion of TAG-enriched VLDL1-type particles into the secretion of TAG poor VLDL2-type particles under insulin stimulus was more pronounced in ANGPTL3 silenced cells compared with control cells suggesting elevated insulin sensitivity.

Mice lacking the GM3 synthase (GMS) have elevated insulin sensitivity [12].

Also LID mice crossed with GHR antagonist transgenic mice were shown to have improved insulin sensitivity despite elevated FFA levels [32].

Very interestingly, it was recently shown that endurance trained athletes are also not characterized by low, but rather by increased DAG levels in skeletal muscle [32], consistent with our observation of elevated DAG levels and improved insulin sensitivity.

This can be viewed as a compensatory upregulation of circulating insulin in response to continued elevated blood glucose and diminished insulin sensitivity, and is a status strongly associated with overweight and obesity.

These findings implicate that especially in case of increased delivery of free fatty acids (i.e. high fat feeding) to skeletal muscle, enhanced intramuscular lipid turnover together with the improvement in markers of mitochondrial function and biogenesis might be responsible for the improved skeletal muscle insulin sensitivity, even despite elevated muscle DAG levels.

In humans, exercise-induced stimulation of insulin sensitivity correlates with elevated AMPK activity.

Data from the IRIS-II (study on insulin resistance and insulin sensitivity) show that elevated proinsulin levels (>10 pmpl/L) are a good indirect marker for insulin resistance (27).