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Homocysteine, a toxic amino-acid metabolite elevated in functional folate deficiency, is a highly sensitive marker of folate status.
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For example, it is unknown whether human RTL1 expression is actually elevated in the absence of functional RTL1as-encoded microRNAs.
We have previously reported that homocysteine levels are elevated in euthymic bipolar patients with functional deterioration.
The human EIF2C1 gene is ubiquitously expressed at low to medium levels, and EIF2C1 expression was found to be elevated in Wilms tumors that lacked functional copies of the Wilms tumor suppressor gene WT1 [ 14].
This hypothesis can, however, be tested by exploring whether symptoms as seen in somatization disorder are elevated in a self-reported past non-functional disorder, i.e. fractures of hand or wrist.
Histone H2B-like (TC15937_1), a functional posttranslational modificator [ 50], elevated in the expression as primary requirement for cellular proliferation [ 51] and down-regulated exclusively in d16, indicating the cellular metabolism and replacement weaken in the later stage of RJ secretion.
However, as the expression of EHD4, a related family member, was elevated in the glomerular endothelium of Ehd3 /– mice and suggested functional compensation, we generated and analyzed Ehd3 /–; Ehd4–/– mice.
Although extracellular proteasome is known to be elevated in a number of inflammatory processes reports of its functional role during inflammation are scarce.
CTGF (CCN2) is a multi-functional matricellular protein whose levels are elevated in both myocytes and myofibroblasts in the infarcted zone after experimental MI [ 73].
One study found that myocardial AGAT mRNA expression, and enzyme activity were elevated in heart failure compared with controls and returned to normal after functional normalization and recovery.
The functional circulating bioactive TNF was significantly (P < 0.001) more elevated in subset with a good biological response than bad responders.
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