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The shift from the elevated expression of multiple chemokines during estrus to the elevated expression of only CCL4 during pregnancy (Fig. 2) might cause a change in the type of cell recruited and/or retained.
Similarly, elevated expression of multiple operons encoding ABC transporters for branched-chain amino acid transportation was observed.
Elevated expression of multiple protein biosynthesis genes is a prominent feature of the transcriptome of hibernating black bears in all organs studied to date in black bears.
These authors demonstrated elevated expression of multiple innate and adaptive immune mediators consistent with tissue injury response, Th1-type T cell response, and suppression of counterregulatory pathways.
Blockade of IL-10 in vivo resulted in enhanced lung inflammation, elevated expression of multiple cytokines and chemokines in the infected lungs, and increased mortality, but with no effect on virus titer or clearance.
Thus, in the case of other lin-35 -synthetic mutants, the proximal cause of the observed defects may not be due to the strongly elevated expression of multiple loci, and therefore these phenotypes may not be effectively alleviated by decreased protein synthesis.
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Many recent reports have demonstrated elevated expression of TG2 in multiple metastatic tumors and those resistant to chemotherapy [2], [3], [11], [33] [36] and its expression has been implicated in disease progression.
Several reports have documented elevated expression of TG2 in multiple cancer cell types [ 27, 28].
We observed overall elevated expression of snoRNAs and their ribonucleoproteins in multiple cancer types.
15 Additionally, in preclinical studies with tumor cell models and xenografts, ixabepilone showed low susceptibility to several important cellular mechanisms that render multiple classes of therapy ineffective, including elevated expression of drug efflux transporter proteins (eg, P-glycoprotein and multiple-resistance protein-1).
These findings fit with the multiple reports indicating elevated expression of Sema3C in highly malignant human tumours and suggest the ability of tumour cells to switch Sema3C function from an anti-angiogenic to a growth-promoting one, by means of proteolytic processing.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com